MOTS-c 20mg
Mitochondria-derived peptide MOTS-c for AMPK activation, insulin sensitivity, and metabolic health.
- Strength
- 20mg
- Size
- 5mL
- Format
- injectable
- Price
- $135
These products are intended for research and educational purposes only. They have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Not for human consumption. Read full disclaimer
Description
What is MOTS-c?
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a peptide encoded by mitochondrial DNA — not the nuclear genome, making it unique among known peptides. Discovered in 2015, it has quickly drawn research interest for its role in regulating metabolism, insulin sensitivity, and cellular energy homeostasis. It is sometimes described as an "exercise mimetic" for its ability to activate metabolic pathways associated with physical activity.
How It Works
MOTS-c primarily activates AMPK (AMP-activated protein kinase), a master regulator of cellular energy balance. AMPK activation triggers pathways that increase glucose uptake into cells, improve fat oxidation, and enhance mitochondrial function — effects similar to those produced by aerobic exercise. Research also suggests MOTS-c plays a role in regulating the folate and methionine cycle, linking mitochondrial function to broader metabolic regulation.
Key Benefits
Studies have linked MOTS-c to improved insulin sensitivity, reduced fat accumulation, and enhanced physical endurance in preclinical models. In aging research, higher circulating MOTS-c levels are associated with healthier metabolic profiles. Human research is still in early stages, but the peptide is used in integrative and longevity medicine practices for metabolic support, weight management assistance, and energy optimization — often as part of a broader protocol with NAD+ or GLP-1 therapies.
What to Expect
MOTS-c is administered via subcutaneous injection, typically several times per week. Some users report increased energy, improved exercise recovery, and better blood sugar stability over a 4–8 week period. Because the human research base is still developing, MOTS-c is most often used in clinical research or integrative medicine settings with close physician oversight. Dosing protocols are individualized based on health goals.
Quality & Sourcing
Every MOTS-c formulation from Greenstone Peptides is compounded in the USA by licensed pharmacy partners under USP 797 sterile standards. Each batch is third-party tested for potency, sterility, and endotoxin.
Storage
Refrigerate at 2–8°C.